semliki forest virus การใช้

• The Sindbis virus and Semliki Forest virus have been used to build recombinant alphavirus replicons.
• Since Semliki Forest virus naturally infects cells of the central nervous system it has been pre-clinically tested as an oncolytic virus against the severe brain tumour type glioblastoma.
• The "'Semliki Forest virus "'was first isolated from mosquitoes in the Semliki Forest, Uganda by the Uganda Virus Research Institute in 1942 and described by Smithburn & Haddow.
• Alphaviruses are of interest to gene therapy researchers, in particular the Ross River virus, Sindbis virus, Semliki Forest virus, and Venezuelan equine encephalitis virus have all been used to develop viral vectors for gene delivery.
• After completing his PhD in medicine in 1964, he began a postdoctoral fellowship at Rockefeller University in MRC Laboratory for Molecular Biology in Cambridge, the group started investigating a Semliki forest virus, introduced to Simons by K滗ri鋓nenem.
• Sindbis virus, geographically restricted to the Old World, is more closely related to the eastern equine encephalitis subgroup, which are New World viruses, than it is to the Semliki Forest virus subgroup which is also found in the Old World.
• There are three subgroups in this genus : the Semliki Forest virus subgroup ( Semliki Forest, O'nyong-nyong and Ross River viruses ); the eastern equine encephalitis virus subgroup ( eastern equine encephalitis and Venezuelan equine encephalitis viruses ) and the Sindbis virus subgroup.
• One advantage offered by serological diagnosis is that serum IgM is detectable from 5 days to months after the onset of symptoms, but drawbacks are that results may require two to three days, and false positives can occur with infection due to other related viruses, such as o'nyong'nyong virus and Semliki Forest virus.